Application
MRVI1 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the MRVI1 antibody detected the MRVI1 protein (arrow).Application
MRVI1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MRVI1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | MRVI1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IRAG, JAW1L |
|---|---|
| Alternative Names | MRVI1 IRAG JAW1L Protein MRVI1 Inositol 1 4 5-trisphosphate receptor-associated cGMP kinase substrate JAW1-related protein MRVI1 |
| Molecular Weight(MW) | 96145 Da |
| Function | Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation |
| Tissue Specificity | Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines |
| Cellular Localization | Cytoplasm, perinuclear region. Sarcoplasmic reticulum (By similarity). Membrane; Single-pass membrane protein (Potential) |
| Entrez Gene | 10335 |
|---|---|
| Nucleotide Accession | NP_001092049.1 NP_569056.3 |
Application
MRVI1 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the MRVI1 antibody detected the MRVI1 protein (arrow).
Application
MRVI1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MRVI1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
