Application
MSL1 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MSL1 antibody detected the MSL1 protein (arrow).| Product Name | MSL1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MSL1; MSL1L1; Male-specific lethal 1 homolog; Male-specific lethal 1-like 1; Male-specific lethal-1 homolog 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MSL1L1 |
|---|---|
| Alternative Names | MSL1 MSL1L1 Male-specific lethal 1 homolog Male-specific lethal 1-like 1 Male-specific lethal-1 homolog 1 |
| Molecular Weight(MW) | 67128 Da |
| Function | Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 |
| Tissue Specificity | This MSL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 338-367 amino acids from the Central region of human MSL1. |
| Cellular Localization | Nucleus. |
| Entrez Gene | 339287 |
|---|---|
| Nucleotide Accession | NP_001012241.1 |
Application
MSL1 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MSL1 antibody detected the MSL1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
