Application
MSL2 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MSL2 antibody detected the MSL2 protein (arrow).| Product Name | MSL2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MSL2; KIAA1585; MSL2L1; RNF184; Male-specific lethal 2 homolog; Male-specific lethal 2-like 1; Male-specific lethal-2 homolog 1; RING finger protein 184 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1585 MSL2L1 RNF184 |
|---|---|
| Alternative Names | MSL2 KIAA1585 MSL2L1 RNF184 Male-specific lethal 2 homolog Male-specific lethal 2-like 1 Male-specific lethal-2 homolog 1 RING finger protein 184 |
| Molecular Weight(MW) | 62541 Da |
| Function | Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 |
| Tissue Specificity | This MSL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human MSL2. |
| Entrez Gene | 55167 |
|---|---|
| Nucleotide Accession | NP_001138889.1 NP_060603.2 |
Application
MSL2 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MSL2 antibody detected the MSL2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
