Application
MX1 Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the MX1 antibody detected the MX1 protein (arrow).| Product Name | MX1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MX1; Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; Myxovirus resistance protein 1; Interferon-induced GTP-binding protein Mx1, N-terminally |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | MX1 Interferon-induced GTP-binding protein Mx1 Interferon-induced protein p78 Interferon-regulated resistance GTP-binding protein MxA Myxoma resistance protein 1 Myxovirus resistance protein 1 Interferon-induced GTP-binding protein Mx1 N-terminally |
|---|---|
| Molecular Weight(MW) | 75520 Da |
| Function | Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs |
| Tissue Specificity | This MX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-437 amino acids from the Central region of human MX1. |
| Cellular Localization | Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids. Co-localizes with CCHFV protein N in the perinuclear region |
| Entrez Gene | 4599 |
|---|---|
| Nucleotide Accession | NP_001138397.1 NP_002453.2 |
Application
MX1 Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the MX1 antibody detected the MX1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
