Application
NDFIP1 Antibody (Center) western blot analysis in human normal Uterus tissue lysates (35ug/lane).This demonstrates the NDFIP1 antibody detected the NDFIP1 protein (arrow).| Product Name | NDFIP1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NDFIP1; N4WBP5; NEDD4 family-interacting protein 1; Breast cancer-associated protein SGA-1M; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | N4WBP5 |
|---|---|
| Alternative Names | NDFIP1 N4WBP5 NEDD4 family-interacting protein 1 Breast cancer-associated protein SGA-1M NEDD4 WW domain-binding protein 5 Putative MAPK-activating protein PM13 Putative NF-kappa-B-activating protein 164 Putative NFKB and MAPK-activating protein |
| Molecular Weight(MW) | 24899 Da |
| Function | Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate |
| Tissue Specificity | Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung |
| Cellular Localization | Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane (By similarity). Secreted Note=Detected in exosomes and secreted via the exosomal pathway |
| Entrez Gene | 80762 |
|---|---|
| Nucleotide Accession | NP_085048.1 |
Application
NDFIP1 Antibody (Center) western blot analysis in human normal Uterus tissue lysates (35ug/lane).This demonstrates the NDFIP1 antibody detected the NDFIP1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
