Application
NEDD4L Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the NEDD4L antibody detected the NEDD4L protein (arrow).| Product Name | NEDD4L Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NEDD4L; KIAA0439; NEDL3; E3 ubiquitin-protein ligase NEDD4-like; NEDD4.2; Nedd4-2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0439 NEDL3 |
|---|---|
| Alternative Names | NEDD4L KIAA0439 NEDL3 E3 ubiquitin-protein ligase NEDD4-like NEDD4.2 Nedd4-2 |
| Molecular Weight(MW) | 111932 Da |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2 |
| Tissue Specificity | Ubiquitously expressed, with highest levels in prostate, pancreas and kidney |
| Cellular Localization | Cytoplasm. Note=May be recruited to exosomes by NDFIP1 |
| Entrez Gene | 23327 |
|---|---|
| Nucleotide Accession | NP_001138436.1 NP_001138442.1 NP_001138439.1 |
Application
NEDD4L Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the NEDD4L antibody detected the NEDD4L protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
