Application
NEIL2 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NEIL2 antibody detected the NEIL2 protein (arrow).| Product Name | NEIL2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NEIL2; Endonuclease 8-like 2; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Endonuclease VIII-like 2; Nei homolog 2; Nei-like protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | NEIL2 Endonuclease 8-like 2 DNA glycosylase/AP lyase Neil2 DNA-(apurinic or apyrimidinic site) lyase Neil2 Endonuclease VIII-like 2 Nei homolog 2 Nei-like protein 2 |
|---|---|
| Molecular Weight(MW) | 36826 Da |
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates |
| Tissue Specificity | Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver |
| Cellular Localization | Nucleus. |
| Entrez Gene | 252969 |
|---|---|
| Nucleotide Accession | NP_001129220.1 NP_001129218.1 NP_659480.1 |
Application
NEIL2 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NEIL2 antibody detected the NEIL2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
