Application
NLGN2 Antibody (C-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the NLGN2 antibody detected the NLGN2 protein (arrow).| Product Name | NLGN2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1366 |
|---|---|
| Alternative Names | NLGN2 KIAA1366 Neuroligin-2 |
| Molecular Weight(MW) | 90820 Da |
| Function | Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity) |
| Tissue Specificity | Expressed in the blood vessel walls. Detected in colon, brian and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity) |
| Entrez Gene | 57555 |
|---|---|
| Nucleotide Accession | NP_065846.1 |
Application
NLGN2 Antibody (C-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the NLGN2 antibody detected the NLGN2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
