Application
NLRC4 Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the NLRC4 antibody detected the NLRC4 protein (arrow).| Product Name | NLRC4 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CARD12, CLAN, CLAN1, IPAF |
|---|---|
| Alternative Names | NLRC4 CARD12 CLAN CLAN1 IPAF NLR family CARD domain-containing protein 4 CARD LRR and NACHT-containing protein Caspase recruitment domain-containing protein 12 Ice protease-activating factor |
| Molecular Weight(MW) | 116159 Da |
| Function | Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis |
| Tissue Specificity | Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain |
| Cellular Localization | Cytoplasm. Cytoplasm, cytosol (By similarity). Note=Cytoplasmic filaments |
| Entrez Gene | 58484 |
|---|---|
| Nucleotide Accession | NP_067032.3 |
Application
NLRC4 Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the NLRC4 antibody detected the NLRC4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
