Application
NLRP10 Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP10 antibody detected the NLRP10 protein (arrow).| Product Name | NLRP10 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NALP10, NOD8, PYNOD |
|---|---|
| Alternative Names | NLRP10 NALP10 NOD8 PYNOD NACHT LRR and PYD domains-containing protein 10 Nucleotide-binding oligomerization domain protein 8 |
| Molecular Weight(MW) | 75032 Da |
| Function | Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection |
| Tissue Specificity | Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells |
| Cellular Localization | Cytoplasm. Cell membrane. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection |
| Entrez Gene | 338322 |
|---|---|
| Nucleotide Accession | NP_789791.1 |
Application
NLRP10 Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP10 antibody detected the NLRP10 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
