Application
A. Western blot analysis on mouse brain lysates using anti-Phospho-NMDAR2B (pS1303) RabMAb (Cat. #AJ1547a), 1:5000 dilution. Cells were either (A) untreated (B) treated with AP| Product Name | NMDAR2B Antibody Phospho (pS1303) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification | p-S1303 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1858Y |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:1000~5000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NMDAR2B |
|---|---|
| Alternative Names | GRIN2B NMDAR2B Glutamate [NMDA] receptor subunit epsilon-2 N-methyl-D-aspartate receptor subunit 3 |
| Molecular Weight(MW) | 166367 Da |
| Function | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) |
| Tissue Specificity | Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein |
| Entrez Gene | 2904 |
|---|
Application
A. Western blot analysis on mouse brain lysates using anti-Phospho-NMDAR2B (pS1303) RabMAb (Cat. #AJ1547a), 1:5000 dilution. Cells were either (A) untreated (B) treated with AP| Application Notes | WB:1:1000~5000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
