Application
NOXO1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the NOXO1 antibody detected the NOXO1 protein (arrow).| Product Name | NOXO1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NOXO1; P41NOX; SH3PXD5; NADPH oxidase organizer 1; NADPH oxidase regulatory protein; Nox organizer 1; Nox-organizing protein 1; SH3 and PX domain-containing protein 5 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | P41NOX SH3PXD5 |
|---|---|
| Alternative Names | NOXO1 P41NOX SH3PXD5 NADPH oxidase organizer 1 NADPH oxidase regulatory protein Nox organizer 1 Nox-organizing protein 1 SH3 and PX domain-containing protein 5 |
| Molecular Weight(MW) | 41253 Da |
| Function | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity |
| Tissue Specificity | Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis |
| Cellular Localization | Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner |
| Entrez Gene | 124056 |
|---|---|
| Nucleotide Accession | NP_653204.1 NP_751907.1 |
Application
NOXO1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the NOXO1 antibody detected the NOXO1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
