Application
NR2C1 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NR2C1 antibody detected the NR2C1 protein (arrow).| Product Name | NR2C1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NR2C1; TR2; Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor TR2; Testicular receptor 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | TR2 |
|---|---|
| Alternative Names | NR2C1 TR2 Nuclear receptor subfamily 2 group C member 1 Orphan nuclear receptor TR2 Testicular receptor 2 |
| Molecular Weight(MW) | 67315 Da |
| Function | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation |
| Tissue Specificity | This NR2C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 515-545 amino acids from the C-terminal region of human NR2C1. |
| Cellular Localization | Nucleus (By similarity). Nucleus, PML body (By similarity). Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation (By similarity) |
| Entrez Gene | 7181 |
|---|---|
| Nucleotide Accession | NP_001027458.1 NP_001120834.1 |
Application
NR2C1 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NR2C1 antibody detected the NR2C1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
