Application
NR2E1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the NR2E1 antibody detected the NR2E1 protein (arrow).| Product Name | NR2E1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NR2E1; TLX; Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Protein tailless homolog |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | TLX |
|---|---|
| Alternative Names | NR2E1 TLX Nuclear receptor subfamily 2 group E member 1 Nuclear receptor TLX Protein tailless homolog |
| Molecular Weight(MW) | 42589 Da |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity) May be required to pattern anterior brain differentiation Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells |
| Tissue Specificity | Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus |
| Cellular Localization | Nucleus (By similarity). |
| Entrez Gene | 7101 |
|---|---|
| Nucleotide Accession | NP_003260.1 |
Application
NR2E1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the NR2E1 antibody detected the NR2E1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
