Application
NSMCE1 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the NSMCE1 Antibody detected the NSMCE1 protein (arrow).| Product Name | NSMCE1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | NSMCE1 Non-structural maintenance of chromosomes element 1 homolog |
|---|---|
| Molecular Weight(MW) | 30855 Da |
| Function | Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus |
| Tissue Specificity | This NSMCE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the C-terminal region of human NSMCE1. |
| Cellular Localization | Nucleus. Chromosome, telomere (Probable). |
| Entrez Gene | 197370 |
|---|---|
| Nucleotide Accession | NP_659547.2 |
Application
NSMCE1 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the NSMCE1 Antibody detected the NSMCE1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
