Application
NUMB Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NUMB antibody detected the NUMB protein (arrow).Application
NUMB Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMB Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | NUMB Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:50~100 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | NUMB Protein numb homolog Protein S171 |
|---|---|
| Molecular Weight(MW) | 70804 Da |
| Function | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage |
| Tissue Specificity | This NUMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NUMB. |
| Cellular Localization | Membrane; Peripheral membrane protein. |
| Entrez Gene | 8650 |
|---|---|
| Nucleotide Accession | NP_003735.3 NP_001005743.1 NP_001005745.1 |
Application
NUMB Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NUMB antibody detected the NUMB protein (arrow).
Application
NUMB Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMB Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:50~100 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
