Application
OBFC2B Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the OBFC2B antibody detected the OBFC2B protein (arrow).| Product Name | OBFC2B Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | OBFC2B, SSB1 |
|---|---|
| Alternative Names | NABP2 OBFC2B SSB1 SOSS complex subunit B1 Nucleic acid-binding protein 2 Oligonucleotide/oligosaccharide-binding fold-containing protein 2B Sensor of single-strand DNA complex subunit B1 Sensor of ssDNA subunit B1 Single-stranded DNA-binding protei |
| Molecular Weight(MW) | 22338 Da |
| Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways |
| Tissue Specificity | This OBFC2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-211 amino acids from the C-terminal region of human OBFC2B. |
| Cellular Localization | Nucleus. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent Partial colocalization with RAD51 after ionizing radiation treatment |
| Entrez Gene | 79035 |
|---|---|
| Nucleotide Accession | NP_076973.1 |
Application
OBFC2B Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the OBFC2B antibody detected the OBFC2B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
