POU2F2, OCT2, OTF2, POU domain, class 2, transcription factor 2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
Key Feature
Clonality
Monoclonal
Clone Number
EPR542
Host Species
Rabbit
Tested Applications
WBIHC
WB:1:5000~10000 IHC
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Gene Synonyms
OCT2 OTF2
Alternative Names
POU2F2 OCT2 OTF2 POU domain class 2 transcription factor 2 Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
Molecular Weight(MW)
51209 Da
Function
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter
Tissue Specificity
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147