Application
SLC22A2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SLC22A2 antibody detected the SLC22A2 protein (arrow).| Product Name | SLC22A2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | OCT2 |
|---|---|
| Alternative Names | SLC22A2 OCT2 Solute carrier family 22 member 2 Organic cation transporter 2 |
| Molecular Weight(MW) | 62581 Da |
| Function | Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity |
| Tissue Specificity | Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma |
| Cellular Localization | Membrane; Multi-pass membrane protein (Potential) |
| Entrez Gene | 6582 |
|---|---|
| Nucleotide Accession | NP_003049.1 |
Application
SLC22A2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SLC22A2 antibody detected the SLC22A2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
