Application
OSBP Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the OSBP antibody detected the OSBP protein (arrow).Application
OSBP Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of OSBP Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | OSBP Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | OSBP; OSBP1; Oxysterol-binding protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | OSBP1 |
|---|---|
| Alternative Names | OSBP OSBP1 Oxysterol-binding protein 1 |
| Molecular Weight(MW) | 89421 Da |
| Function | Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability |
| Tissue Specificity | Widely expressed. |
| Cellular Localization | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes |
| Entrez Gene | 5007 |
|---|---|
| Nucleotide Accession | NP_002547.1 |
Application
OSBP Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the OSBP antibody detected the OSBP protein (arrow).
Application
OSBP Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of OSBP Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
