Application
Western blot analysis of Park6 (PINK1)-D309.MT* in mouse cerebellum tissue lysates (35ug/lane). Park6 (arrow) was detected using the purified Pab.| Product Name | Park6 (PINK1)-D309.MT* |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PINK1; Serine/threonine-protein kinase PINK1, mitochondrial; BRPK; PTEN-induced putative kinase protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | PINK1 Serine/threonine-protein kinase PINK1 mitochondrial BRPK PTEN-induced putative kinase protein 1 |
|---|---|
| Molecular Weight(MW) | 62769 Da |
| Function | Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation |
| Tissue Specificity | Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development |
| Cellular Localization | Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm, cytosol |
| Entrez Gene | 65018 |
|---|
Application
Western blot analysis of Park6 (PINK1)-D309.MT* in mouse cerebellum tissue lysates (35ug/lane). Park6 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
