Application
PCGF2 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PCGF2 antibody detected the PCGF2 protein (arrow).| Product Name | PCGF2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PCGF2; MEL18; RNF110; ZNF144; Polycomb group RING finger protein 2; DNA-binding protein Mel-18; RING finger protein 110; Zinc finger protein 144 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MEL18 RNF110 ZNF144 |
|---|---|
| Alternative Names | PCGF2 MEL18 RNF110 ZNF144 Polycomb group RING finger protein 2 DNA-binding protein Mel-18 RING finger protein 110 Zinc finger protein 144 |
| Molecular Weight(MW) | 37788 Da |
| Function | Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity) |
| Tissue Specificity | Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle |
| Cellular Localization | Nucleus. |
| Entrez Gene | 7703 |
|---|---|
| Nucleotide Accession | NP_009075.1 |
Application
PCGF2 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PCGF2 antibody detected the PCGF2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
