Application
PCSK6 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PCSK6 antibody detected the PCSK6 protein (arrow).| Product Name | PCSK6 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PCSK6; PACE4; Proprotein convertase subtilisin/kexin type 6; Paired basic amino acid cleaving enzyme 4; Subtilisin-like proprotein convertase 4; Subtilisin/kexin-like protease PACE4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PACE4 |
|---|---|
| Alternative Names | PCSK6 PACE4 Proprotein convertase subtilisin/kexin type 6 Paired basic amino acid cleaving enzyme 4 Subtilisin-like proprotein convertase 4 Subtilisin/kexin-like protease PACE4 |
| Molecular Weight(MW) | 106420 Da |
| Function | Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif |
| Tissue Specificity | Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary Isoform PACE4E-II is at least present in cerebellum |
| Cellular Localization | Isoform PACE4A-I: Secreted. Isoform PACE4C: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum Isoform PACE4E-I: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus Isoform PACE4B: Secreted. |
| Entrez Gene | 5046 |
|---|---|
| Nucleotide Accession | NP_612197.1 NP_612194.1 NP_612196.1 |
Application
PCSK6 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PCSK6 antibody detected the PCSK6 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
