Application
PDE11A Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the PDE11A antibody detected the PDE11A protein (arrow).Application
PDE11A Antibody (N-term) (AP14002a)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PDE11A Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | PDE11A Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PDE11A; Dual 3', 5'-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | PDE11A Dual 3' 5'-cyclic-AMP and -GMP phosphodiesterase 11A cAMP and cGMP phosphodiesterase 11A |
|---|---|
| Molecular Weight(MW) | 104752 Da |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively |
| Tissue Specificity | Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis Isoform 4 is expressed in adrenal cortex |
| Cellular Localization | Cytoplasm, cytosol. |
| Entrez Gene | 50940 |
|---|---|
| Nucleotide Accession | NP_001070664.1 NP_001070665.1 NP_001070826.1 |
Application
PDE11A Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the PDE11A antibody detected the PDE11A protein (arrow).
Application
PDE11A Antibody (N-term) (AP14002a)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PDE11A Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
