Application
PDE4A Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the PDE4A antibody detected the PDE4A protein (arrow).| Product Name | PDE4A Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PDE4A; DPDE2; cAMP-specific 3', 5'-cyclic phosphodiesterase 4A; PDE46 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DPDE2 |
|---|---|
| Alternative Names | PDE4A DPDE2 cAMP-specific 3' 5'-cyclic phosphodiesterase 4A PDE46 |
| Molecular Weight(MW) | 98143 Da |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes |
| Tissue Specificity | Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level) |
| Cellular Localization | Isoform 1: Cytoplasm, perinuclear region. Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic |
| Entrez Gene | 5141 |
|---|---|
| Nucleotide Accession | NP_001104778.1 NP_001104777.1 |
Application
PDE4A Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the PDE4A antibody detected the PDE4A protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
