Application
PDZD6 Antibody (C-term) western blot analysis in mouse cerebellum tissue lysates (15ug/lane).This demonstrates the PDZD6 antibody detected PDZD6 protein (arrow).Application
PDZD6 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PDZD6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
PDZD6 Antibody (C-term) flow cytometric analysis of A2058 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | PDZD6 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | INTU; KIAA1284; PDZD6; PDZK6; Protein inturned; Inturned planar cell polarity effector homolog; PDZ domain-containing protein 6 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1284 PDZD6 PDZK6 |
|---|---|
| Alternative Names | INTU KIAA1284 PDZD6 PDZK6 Protein inturned Inturned planar cell polarity effector homolog PDZ domain-containing protein 6 |
| Molecular Weight(MW) | 105648 Da |
| Function | Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity) |
| Tissue Specificity | This PDZD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 765-795 amino acids from the C-terminal region of human PDZD6. |
| Cellular Localization | Cytoplasm (By similarity). Cell surface (By similarity). Note=Enriched at the apical surface in ciliated cells (By similarity) |
| Entrez Gene | 27152 |
|---|---|
| Nucleotide Accession | NP_056508.2 |
Application
PDZD6 Antibody (C-term) western blot analysis in mouse cerebellum tissue lysates (15ug/lane).This demonstrates the PDZD6 antibody detected PDZD6 protein (arrow).
Application
PDZD6 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PDZD6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
PDZD6 Antibody (C-term) flow cytometric analysis of A2058 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
