Application
Western blot analysis of PDZRN3 antibody (Center E388) (Cat.# AP7375c) in Y79 cell line lysates (35ug/lane). PDZRN3 (arrow) was detected using the purified Pab.Application
Formalin-fixed and paraffin-embedded human skeletal muscle reacted with PDZRN3 Antibody (Center E388), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Product Name | PDZRN3 Antibody (Center E388) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PDZRN3; KIAA1095; LNX3; SEMCAP3; E3 ubiquitin-protein ligase PDZRN3; Ligand of Numb protein X 3; PDZ domain-containing RING finger protein 3; Semaphorin cytoplasmic domain-associated protein 3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:50~100 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1095 LNX3 SEMCAP3 |
|---|---|
| Alternative Names | PDZRN3 KIAA1095 LNX3 SEMCAP3 E3 ubiquitin-protein ligase PDZRN3 Ligand of Numb protein X 3 PDZ domain-containing RING finger protein 3 Semaphorin cytoplasmic domain-associated protein 3 |
| Molecular Weight(MW) | 119596 Da |
| Function | E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity) |
| Tissue Specificity | Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors |
| Entrez Gene | 23024 |
|---|
Application
Western blot analysis of PDZRN3 antibody (Center E388) (Cat.# AP7375c) in Y79 cell line lysates (35ug/lane). PDZRN3 (arrow) was detected using the purified Pab.
Application
Formalin-fixed and paraffin-embedded human skeletal muscle reacted with PDZRN3 Antibody (Center E388), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Application Notes | WB:1:50~100 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
