Application
PELI2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PELI2 antibody detected the PELI2 protein (arrow).| Product Name | PELI2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PELI2; E3 ubiquitin-protein ligase pellino homolog 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | PELI2 E3 ubiquitin-protein ligase pellino homolog 2 |
|---|---|
| Molecular Weight(MW) | 46435 Da |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1 |
| Tissue Specificity | This PELI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from the N-terminal region of human PELI2. |
| Entrez Gene | 57161 |
|---|---|
| Nucleotide Accession | NP_067078.1 |
Application
PELI2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PELI2 antibody detected the PELI2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
