Application
Abgent invites you to submit your data (IHC, IF, IP, WB, FC) using this product. We will award you credits, 50% of the cost you paid, for future purchases. For availability of this promotion please contact us at tech@abgent.com.| Product Name | PEN2 Antibody (C-term Q79) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PSENEN; PEN2; Gamma-secretase subunit PEN-2; Presenilin enhancer protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PEN2 |
|---|---|
| Alternative Names | PSENEN PEN2 Gamma-secretase subunit PEN-2 Presenilin enhancer protein 2 |
| Molecular Weight(MW) | 12029 Da |
| Function | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity |
| Tissue Specificity | Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi |
| Entrez Gene | 55851 |
|---|
Application
Abgent invites you to submit your data (IHC, IF, IP, WB, FC) using this product. We will award you credits, 50% of the cost you paid, for future purchases. For availability of this promotion please contact us at tech@abgent.com.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
