Application
PHF21A Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the PHF21A antibody detected the PHF21A protein (arrow).| Product Name | PHF21A Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PHF21A; BHC80; KIAA1696; PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BHC80 KIAA1696 |
|---|---|
| Alternative Names | PHF21A BHC80 KIAA1696 PHD finger protein 21A BHC80a BRAF35-HDAC complex protein BHC80 |
| Molecular Weight(MW) | 74854 Da |
| Function | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation |
| Tissue Specificity | Highly expressed in brain. Expressed at much lower level in other tissues |
| Cellular Localization | Nucleus (By similarity). |
| Entrez Gene | 51317 |
|---|---|
| Nucleotide Accession | NP_057705.3 |
Application
PHF21A Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the PHF21A antibody detected the PHF21A protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
