Application
Dot blot analysis of anti-Phospho-LINGO-1(LRRN6A)-pS596 Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.| Product Name | Phospho-LINGO-1(LRRN6A)-pS596 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification | p-S596 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | DB |
| DB:1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Lern1, Lrrn6a |
|---|---|
| Alternative Names | Lingo1 Lern1 Lrrn6a Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Leucine-rich repeat neuronal protein 1 Leucine-rich repeat neuronal protein 6A |
| Molecular Weight(MW) | 69101 Da |
| Function | Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development |
| Tissue Specificity | Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Entrez Gene | 235402 |
|---|
Application
Dot blot analysis of anti-Phospho-LINGO-1(LRRN6A)-pS596 Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.| Application Notes | DB:1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
