Application
Dot blot analysis of anti-Phospho-PHB2-pY248 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.| Product Name | Phospho-PHB2-pY248 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PHB2; BAP; REA; Prohibitin-2; B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity |
| Modification | p-Y248 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | DB |
| DB:1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BAP REA |
|---|---|
| Alternative Names | PHB2 BAP REA Prohibitin-2 B-cell receptor-associated protein BAP37 D-prohibitin Repressor of estrogen receptor activity |
| Molecular Weight(MW) | 33296 Da |
| Function | Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging |
| Tissue Specificity | This Phospho-PHB2-pY248 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 233~262 amino acids surrounding Y248 of human PHB2. |
| Cellular Localization | Mitochondrion inner membrane (By similarity). Cytoplasm (By similarity). Nucleus (By similarity) Note=Also cytoplasmic and nuclear (By similarity) |
Application
Dot blot analysis of anti-Phospho-PHB2-pY248 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.| Application Notes | DB:1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
