Application
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with PI3KC2B antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Product Name | PI3KC2B Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PIK3C2B; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; C2-PI3K; Phosphoinositide 3-kinase-C2-beta |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:10~50 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta C2-PI3K Phosphoinositide 3-kinase-C2-beta |
|---|---|
| Molecular Weight(MW) | 184768 Da |
| Function | Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades |
| Tissue Specificity | Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney |
| Cellular Localization | Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis |
| Entrez Gene | 5287 |
|---|
Application
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with PI3KC2B antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Application Notes | IHC:1:10~50 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
