Application
Western blot analysis of Park6(PINK1) (arrow) using rabbit polyclonal Park6(PINK1) Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Park6(PINK1) gene.Application
Park6 (PINK1) Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the Park6 (PINK1) antibody detected the Park6 (PINK1) protein (arrow).| Product Name | PINK1 (PARK6) Antibody (N-term T133) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PINK1; Serine/threonine-protein kinase PINK1, mitochondrial; BRPK; PTEN-induced putative kinase protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | PINK1 Serine/threonine-protein kinase PINK1 mitochondrial BRPK PTEN-induced putative kinase protein 1 |
|---|---|
| Molecular Weight(MW) | 62769 Da |
| Function | Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation |
| Tissue Specificity | Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development |
| Cellular Localization | Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm, cytosol |
Application
Western blot analysis of Park6(PINK1) (arrow) using rabbit polyclonal Park6(PINK1) Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Park6(PINK1) gene.
Application
Park6 (PINK1) Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the Park6 (PINK1) antibody detected the Park6 (PINK1) protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
