Application
PITRM1 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PITRM1 antibody detected the PITRM1 protein (arrow).| Product Name | PITRM1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PITRM1; KIAA1104; MP1; Presequence protease, mitochondrial; Pitrilysin metalloproteinase 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1104 MP1 |
|---|---|
| Alternative Names | PITRM1 KIAA1104 MP1 Presequence protease mitochondrial Pitrilysin metalloproteinase 1 |
| Molecular Weight(MW) | 117455 Da |
| Function | ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference |
| Tissue Specificity | Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta |
| Cellular Localization | Mitochondrion matrix. |
| Entrez Gene | 10531 |
|---|---|
| Nucleotide Accession | NP_055704.2 |
Application
PITRM1 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PITRM1 antibody detected the PITRM1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
