Application
PLA2G3 Antibody (C-term) western blot analysis in Uterus tissue lysates (35ug/lane).This demonstrates the PLA2G3 antibody detected the PLA2G3 protein (arrow).| Product Name | PLA2G3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PLA2G3; Group 3 secretory phospholipase A2; Group III secretory phospholipase A2; Phosphatidylcholine 2-acylhydrolase 3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | PLA2G3 Group 3 secretory phospholipase A2 Group III secretory phospholipase A2 Phosphatidylcholine 2-acylhydrolase 3 |
|---|---|
| Molecular Weight(MW) | 57167 Da |
| Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC) Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis |
| Tissue Specificity | Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and alveolar macrophages, but scarcely detected in alveolar epithelium, arterial walls and interstitial fibroblasts (at protein level). In joints of osteoarthritis and rheumatoid arthritis, expressed in endothelial cells (at protein level). In normal heart, detected in some vessels. In myocardial tissues with acute infarction, expressed in vascular endothelial cells adjacent to cardiomyocytes and those in lesions with granulation Expression in cardiomyocytes is scarce (at protein level). In uterus, breast and colon cancers, detected in tumor cells and neighboring microvascular endothelium, but not in normal glandular tissues (at protein level) |
| Cellular Localization | Secreted. Cell membrane. Cytoplasm, cytoskeleton, centrosome, centriole |
| Entrez Gene | 50487 |
|---|---|
| Nucleotide Accession | NP_056530.2 |
Application
PLA2G3 Antibody (C-term) western blot analysis in Uterus tissue lysates (35ug/lane).This demonstrates the PLA2G3 antibody detected the PLA2G3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
