The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling
Tissue Specificity
A synthetic peptide corresponding to residues near the C-terminus of human PLCγII was used as an immunogen.