Application
PLEKHA8 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PLEKHA8 antibody detected the PLEKHA8 protein (arrow).| Product Name | PLEKHA8 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PLEKHA8; FAPP2; Pleckstrin homology domain-containing family A member 8; Phosphatidylinositol-four-phosphate adapter protein 2; Serologically defined breast cancer antigen NY-BR-86 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FAPP2 |
|---|---|
| Alternative Names | PLEKHA8 FAPP2 Pleckstrin homology domain-containing family A member 8 Phosphatidylinositol-four-phosphate adapter protein 2 Serologically defined breast cancer antigen NY-BR-86 |
| Molecular Weight(MW) | 58261 Da |
| Function | Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation |
| Tissue Specificity | Expressed in kidney cell lines. |
| Cellular Localization | Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes |
| Entrez Gene | 84725 |
|---|---|
| Nucleotide Accession | NP_116028.1 |
Application
PLEKHA8 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PLEKHA8 antibody detected the PLEKHA8 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
