Application
PLEKHF1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PLEKHF1 antibody detected the PLEKHF1 protein (arrow).| Product Name | PLEKHF1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PLEKHF1; APPD; LAPF; ZFYVE15; Pleckstrin homology domain-containing family F member 1; Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains; PH and FYVE domain-containing protein 1; Phafin-1; Zinc finger FYVE domain-containing prot |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | APPD LAPF ZFYVE15 |
|---|---|
| Alternative Names | PLEKHF1 APPD LAPF ZFYVE15 Pleckstrin homology domain-containing family F member 1 Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains PH and FYVE domain-containing protein 1 Phafin-1 Zinc finger FYVE domain-containing prot |
| Molecular Weight(MW) | 31195 Da |
| Function | May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 |
| Tissue Specificity | Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung |
| Cellular Localization | Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis |
| Entrez Gene | 79156 |
|---|---|
| Nucleotide Accession | NP_077286.3 |
Application
PLEKHF1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PLEKHF1 antibody detected the PLEKHF1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
