Application
PPP1R16B Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PPP1R16B antibody detected the PPP1R16B protein (arrow).| Product Name | PPP1R16B Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PPP1R16B; ANKRD4; KIAA0823; Protein phosphatase 1 regulatory inhibitor subunit 16B; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ANKRD4 KIAA0823 |
|---|---|
| Alternative Names | PPP1R16B ANKRD4 KIAA0823 Protein phosphatase 1 regulatory inhibitor subunit 16B Ankyrin repeat domain-containing protein 4 CAAX box protein TIMAP TGF-beta-inhibited membrane-associated protein |
| Molecular Weight(MW) | 63551 Da |
| Function | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells |
| Tissue Specificity | Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis |
| Cellular Localization | Cell membrane. Cell membrane; Lipid-anchor (Potential). Nucleus. Note=Co-localizes with RPSA/LAMR1 in the cell membrane |
| Entrez Gene | 26051 |
|---|---|
| Nucleotide Accession | NP_001166206.1 |
Application
PPP1R16B Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PPP1R16B antibody detected the PPP1R16B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
