Application
PPP1R3B Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PPP1R3B antibody detected the PPP1R3B protein (arrow).| Product Name | PPP1R3B Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PPP1R3B; PPP1R4; Protein phosphatase 1 regulatory subunit 3B; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Protein phosphatase 1 regulatory subunit 4; Protein phosphatase 1 subunit GL |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PPP1R4 |
|---|---|
| Alternative Names | PPP1R3B PPP1R4 Protein phosphatase 1 regulatory subunit 3B Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL Protein phosphatase 1 regulatory subunit 4 Protein phosphatase 1 subunit GL |
| Molecular Weight(MW) | 32695 Da |
| Function | Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1 Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity) |
| Tissue Specificity | Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expression in placenta and lung |
| Entrez Gene | 79660 |
|---|---|
| Nucleotide Accession | NP_078883.2 |
Application
PPP1R3B Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PPP1R3B antibody detected the PPP1R3B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
