Application
PRDM6 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PRDM6 antibody detected the PRDM6 protein (arrow).| Product Name | PRDM6 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PRDM6; PFM3; Putative histone-lysine N-methyltransferase PRDM6; PR domain zinc finger protein 6; PR domain-containing protein 6 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PFM3 |
|---|---|
| Alternative Names | PRDM6 PFM3 Putative histone-lysine N-methyltransferase PRDM6 PR domain zinc finger protein 6 PR domain-containing protein 6 |
| Molecular Weight(MW) | 64452 Da |
| Function | Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity) |
| Tissue Specificity | This PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human PRDM6. |
| Cellular Localization | Nucleus (By similarity). |
| Entrez Gene | 93166 |
|---|---|
| Nucleotide Accession | NP_001129711.1 |
Application
PRDM6 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PRDM6 antibody detected the PRDM6 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
