Application
Western blot analysis of anti-PSN2/1 Pab in mouse kidney tissue lysate (35ug/lane). PSN2/1(arrow) was detected using the purified Pab.Application
Confocal immunofluorescent analysis of Presenilin 2/1 (PSEN2/PSEN1) Antibody (N-term)(Cat#AP6304c) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).| Product Name | Presenilin 2/1 (PSEN2/PSEN1) Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PSEN2; AD4; PS2; PSNL2; STM2; Presenilin-2; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIF |
| WB:1:100~500 IF |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | AD4 PS2 PSNL2 STM2 |
|---|---|
| Alternative Names | PSEN2 AD4 PS2 PSNL2 STM2 Presenilin-2 AD3LP AD5 E5-1 STM-2 Presenilin-2 NTF subunit Presenilin-2 CTF subunit |
| Molecular Weight(MW) | 50140 Da |
| Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins |
| Tissue Specificity | Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
| Entrez Gene | 5664 |
|---|
Application
Western blot analysis of anti-PSN2/1 Pab in mouse kidney tissue lysate (35ug/lane). PSN2/1(arrow) was detected using the purified Pab.
Application
Confocal immunofluorescent analysis of Presenilin 2/1 (PSEN2/PSEN1) Antibody (N-term)(Cat#AP6304c) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).| Application Notes | WB:1:100~500 IF |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
