Application
A. Western blot analysis on HeLa cell lysates using anti-Phospho Presenilin 2 (pS327) RabMAb (Cat. #AJ1651b), dilution 1:5,000. Cells were either (A) untreated (B) treated with AP.| Product Name | Presenilin-2 Antibody Phospho (pS327) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PSEN2, AD4, PS2, PSNL2, STM2, Presenilin-2 CTF subunit, STM-2;E5-1;AD3LP;AD5 |
| Modification | p-S327 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP2613Y |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:1000~5000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | AD4 PS2 PSNL2 STM2 |
|---|---|
| Alternative Names | PSEN2 AD4 PS2 PSNL2 STM2 Presenilin-2 CTF subunit STM-2 E5-1 AD3LP AD5 |
| Molecular Weight(MW) | 50140 Da |
| Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins |
| Tissue Specificity | Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
| Entrez Gene | 5664 |
|---|
Application
A. Western blot analysis on HeLa cell lysates using anti-Phospho Presenilin 2 (pS327) RabMAb (Cat. #AJ1651b), dilution 1:5,000. Cells were either (A) untreated (B) treated with AP.| Application Notes | WB:1:1000~5000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
