Application
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PRKX antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Product Name | PRKX Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PRKX; PKX1; cAMP-dependent protein kinase catalytic subunit PRKX; Protein kinase PKX1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:10~50 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PKX1 |
|---|---|
| Alternative Names | PRKX PKX1 cAMP-dependent protein kinase catalytic subunit PRKX Protein kinase PKX1 |
| Molecular Weight(MW) | 40896 Da |
| Function | Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation |
| Tissue Specificity | Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982 |
| Cellular Localization | Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation |
| Entrez Gene | 5613 |
|---|
Application
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PRKX antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Application Notes | IHC:1:10~50 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
