Application
PVRL3 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PVRL3 antibody detected the PVRL3 protein (arrow).| Product Name | PVRL3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PRR3 |
|---|---|
| Alternative Names | PVRL3 PRR3 Poliovirus receptor-related protein 3 CDw113 Nectin-3 CD_antigen=CD113 Flags: Precursor |
| Molecular Weight(MW) | 61002 Da |
| Function | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body |
| Tissue Specificity | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines |
| Cellular Localization | Cell membrane; Single-pass membrane protein (Potential) |
| Entrez Gene | 25945 |
|---|---|
| Nucleotide Accession | NP_056295.1 |
Application
PVRL3 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PVRL3 antibody detected the PVRL3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
