PXK PX domain-containing protein kinase-like protein Modulator of Na K-ATPase
Molecular Weight(MW)
64950 Da
Function
Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity
Tissue Specificity
Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated
Cellular Localization
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma membrane Isoform 3 is present throughout the cell
Western blot analysis of PXK Antibody (N-term) in Jurkat cell line lysates (35ug/lane). PXK (arrow) was detected using the purified Pab.
Application Notes
WB:1:100~500
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.