RAB3GAP2; KIAA0839; Rab3 GTPase-activating protein non-catalytic subunit; RGAP-iso; Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP regulatory subunit
Key Feature
Clonality
Polyclonal
Isotype
Ig
Host Species
Rabbit
Tested Applications
WB
WB:1:100~500
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Gene Synonyms
KIAA0839
Alternative Names
RAB3GAP2 KIAA0839 Rab3 GTPase-activating protein non-catalytic subunit RGAP-iso Rab3 GTPase-activating protein 150 kDa subunit Rab3-GAP p150 Rab3-GAP regulatory subunit
Molecular Weight(MW)
155985 Da
Function
Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters
Tissue Specificity
Ubiquitous.
Cellular Localization
Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction
Western blot analysis of RAB3GAP2 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). RAB3GAP2 (arrow) was detected using the purified Pab.
Application Notes
WB:1:100~500
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.