Application
RAB7B Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RAB7B antibody detected the RAB7B protein (arrow).| Product Name | RAB7B Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RAB7B; Ras-related protein Rab-7b |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | RAB7B Ras-related protein Rab-7b |
|---|---|
| Molecular Weight(MW) | 22511 Da |
| Function | Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1 Not involved in the regulation of the EGF- and EGFR degradation pathway |
| Tissue Specificity | Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte |
| Cellular Localization | Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis |
| Entrez Gene | 338382 |
|---|---|
| Nucleotide Accession | NP_796377.3 |
Application
RAB7B Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RAB7B antibody detected the RAB7B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
