Application
RANBP3 Antibody (N-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the RANBP3 antibody detected the RANBP3 protein (arrow).| Product Name | RANBP3 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RANBP3; Ran-binding protein 3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | RANBP3 Ran-binding protein 3 |
|---|---|
| Molecular Weight(MW) | 60210 Da |
| Function | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export |
| Tissue Specificity | Widely expressed with high levels in testis and heart |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 8498 |
|---|---|
| Nucleotide Accession | NP_015559.2 NP_003615.2 NP_015561.1 |
Application
RANBP3 Antibody (N-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the RANBP3 antibody detected the RANBP3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
